Gawiyou Danialou

• Gene Therapy
• Muscle Regeneration
• Inflammation

PubMed

I am currently involved in three main areas of research related to skeletal muscle. Indeed, skeletal muscle is the most important tissue in mammals and represents 40 to 50% of the total body mass. The maintenance of skeletal muscle mass is essential to maintain good health. In fact, the skeletal muscle functions include motion, respiration and posture control. Skeletal muscles are very important protein reserves that can be mobilized to provide alternative energy substrates for the preservation of critical organs such as the heart, brain and liver. Skeletal muscle protein mobilization usually leads to muscle atrophy, and has been observed under compromised physiological conditions, such as fasting, inactivity, aging, and in response to certain pathologies such as cancer. Protein mobilization is regulated by three distinct pathways: the calpain system, the ubiquinine-proteasome system and the autophagy-lysosomal pathway. Recent studies have confirmed that autophagy plays a critical role in this mobilization process. However, Research in the area of autophagy and skeletal muscle protein mobilization is still in its infancy. My first area of interests is to develop a research program to identify the SNARK (Sucrose nonfermenting AMPK-related kinase) involvement in the loss of muscle mass observed under compromised physiological conditions (fasting, inactivity, aging, diseases) and the mechanisms by which it involved in the process. My second area of interests is to identify the molecules involved in muscle regeneration in order to propose solutions for muscle regeneration improvement after injury. My last area of interests is to improve gene transfer in skeletal muscle by using non-viral vectors.